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CT: the first imaging technique for diagnosis,
grading and surveillance of GEP-NETs

Dear readers,

Gastroenteropancreatic NETs (GEP-NETs) include a wide variety of neuroendocrine tumors affecting the pancreas and gastrointestinal tract. Although relatively rare, they markedly differ in biology, functionality, aggressiveness and metastatic potential, making their characterization and staging challenging.

This month’s Focus on, by Prof. Laghi’s team, illustrates in detail the imaging tools currently available for the diagnosis of GEP-NETs, where a crucial role is played by CT used alone or in combination with PET. As shown by the numerous CT images and cases reported in this Focus on, CT is the primary imaging modality applied for the diagnosis of these tumors and plays a fundamental role in detecting the primary lesion, in staging and assessing tumor functionality and liver metastases with a high level of accuracy and sensitivity.

The selected articles proposed in this Newsletter expand on the topic of this Focus on, by describing in detail the imaging techniques used for the appropriate diagnosis and follow-up of these tumor entities and the recent advancements in this field. 

The two clinical cases of this Newsletter demonstrate the valuable role of CT with contrast medium for a prompt and correct diagnosis of GEP-NETs, and illustrate the typical CT features observed in these patients.

We remind you that suggestions for topics to be covered in future issues of this newsletter are welcomed. Please send us your proposals at

From the team



Gastroenteropancreatic NETs (GEP-NETs)
Daniela Prosperi, Michela Polici, Elisa Rosati, Guido Gentiloni Silveri, Elsa Iannicelli, Andrea Laghi
Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Italy
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Malla S, Kumar P, Seetharama Madhusudhan K. Radiology of the neuroendocrine neoplasms of the gastrointestinal tract: a comprehensive review. Abdom Radiol (NY). 2021 Mar;46(3):919-935.

Olpin J, Fine GC, Shaaban A. Imaging of gastrointestinal neuroendocrine tumors. Curr Radiol Rep. 2020;8(29):1-11.