CM Safety

Other reactions to IV contrast administration

Osmotic/chemotoxic Reactions

• Dose-related
• Immediate
• Usual symptoms
  • Nausea/vomiting
  • Pain
  • Flushing/heat sensation

Note : There are no reported data to support the claim that nonionic contrast media have a significant effect on patient heart rate during intravascular injection. Two studies were conducted in patients who underwent cardiac angiography (N = 120) or peripheral intraarterial digital subtraction angiography (N = 96) in which heart rate was systematically measured before, during, and after injection. In both studies, patients randomly received either a nonionic, low-osmolar monomer or a nonionic, iso-osmolar dimer. There were no significant trends noted in the mean change from baseline in heart rate data for either treatment group in either study.
(Data on file, Bracco Diagnostics" to the 2005 NASCI meeting abstract reference - Meier B, Garachemani A, Fleisch M. Effects of non-ionic iodinated contrast media on patient heart rate during intracardiac or intraarterial injection. Presented at the North American Society of Cardiac Imaging, Amelia Island, Florida, 2005)