MDCT.net's
Guide to Technology and Protocols
CM Safety
Other reactions to IV contrast administration
Delayed Adverse Events
Delayed adverse events (DAEs) can be defined as adverse events occurring 1 hour to as much as 7 days after the administration of iodinated contrast.
- Typical DAEs include
- Skin reactions such as painful itching, skin eruptions, and other maculopapular rashes. These reactions are clearly related to contrast agent administration.
- Other adverse reactions reported include headache, dizziness, nausea, vomiting, diarrhea, chills, and flu-like symptoms. However, the incidence of these delayed reactions in patients who receive contrast media is similar to that reported in patients who receive only noncontrast CT (12.4% vs 10.3%, respectively). 1
- Nonionic dimers such as iodixanol, are associated with a more frequent occurrence of DAEs than
nonionic monomers.
2,3
1. Yasuda R, Munechika H. Delayed adverse reactions to nonionic monomeric
contrast-enhanced media.
Invest Radiol. 1998;33:1-5.
2. Sutton AG, Finn P, Campbell DJ, et al. Early and late reactions following the
use of iopamidol 340, iomeprol 350 and iodixanol 320 in cardiac catheterization.
J Invasive Cardiol. 2003;15:133-138.
3. Sutton AG, Finn P, Grech ED, et al. Early and late reactions after the use of
iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization.
Am Heart J. 2001;141:677-83.
|
