Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography
by JJ Yeh, SCC Chen, WB Ten et al.
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Abstract
Objective
: This study aimed to determine whether characteristics detected by multi-detector
computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary
tuberculosis (PTB).
Methods
: Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2)
smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images
were analysed retrospec- tively for morphology, number, and segmental (lobe) distribution of
lesions.
Results
: By multivariate analysis, consolidation over any segment of the upper, middle, or
lingual lobes, cavitations, and clusters of nodules were associated with group 1, while
centrilobular nodules were predictive of group 2. Using five independent variables associated with
risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC
curve analysis showed an area under the curve of 0.951±0.021 for this prediction model. With the
ideal cutoff point score of 1, the sensitivity, specif- icity, and positive predictive values were
84.5%, 97.5%, and 98.0%, respectively.
Conclusions
: A model to predict smear-positive active PTB on the basis of findings from MDCT may be a
useful tool for clinical decisions about isolating patients pending sputum smear results.
