MDCT.net Patients at Risk - Definition and Risk Factors

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Patients at risk for contrast-induced nephropathy

Definition and Risk Factors

In the absence of other causes, contrast-induced nephropathy (CIN) is an acute decline in renal function after the administration of iodinated contrast media. The most common risk factors for developing CIN are shown in Table 1.

Table 1. Risk Factors for Developing CIN
Established Dehydration Pre-existing renal failure particularly as a result of diabetic nephropathy serum creatinine ≥1.5 mg/dL creatinine clearance <60 mL/min (the better indicator, as it measures glomerular filtration rate) Diabetes mellitus Large contrast volume, or multiple contrast examinations in <48 hrs Class III/IV congestive heart failure Multiple myeloma	Probable Age >70 yrs Concomitant use of loop diuretics Concurrent administration of drugs that are directly nephrotoxic or produce intra-renal vasoconstriction (cyclosporin, aminoglycosides, antineoplastic agents, amphotericin B, dipyridamole, adenosine, etc.)

P. Costello and CR Lowry

Multidetector CT Protocols
Developed for GE, Philips, Siemens,Toshiba Scanners
Springer 2005, 2006